Sperm-like nanocarriers for ultrafast delivery of antisense DNA-Reference-Cited by-同舟云学术

Sperm-like nanocarriers for ultrafast delivery of antisense DNA

Published:2022 Issue:30 Volume:14 Page:10844-10850
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Tang Xiaochen¹²,Chen Tianshu¹²,Chen Huinan³,Yu Sinuo³,Cao Siyu³,Liu Chenbin⁴,Ma Yonggeng³,Sun Fenyong⁴,Pan Qiuhui¹²,Zhu Xiaoli⁴^ORCID

Affiliation:

1. Department of Clinical Laboratory Medicine, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P. R. China

2. Shanghai Key Laboratory of Clinical Molecular Diagnostics for Pediatrics, Shanghai 200127, P. R. China

3. School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China

4. Department of Clinical Laboratory Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai 200072, P. R. China

Abstract

The nano-sperm is developed for ultrafast delivery of antisense DNA into cancer cells. Carried by silver nanoclusters at the “head”, antisense DNA as the cargo at the “tail” can be transported into cells rapidly, thereby inhibiting cell proliferation.

Funder

Program of Shanghai Academic Research Leader

Natural Science Foundation of Shanghai

National Natural Science Foundation of China

Shanghai Education Development Foundation

Shanghai Municipal Education Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NR/D2NR02050E