Synthesis of the 10-oxabicyclo[5.2.1]decane framework present in bioactive natural products-Reference-Cited by-同舟云学术

Synthesis of the 10-oxabicyclo[5.2.1]decane framework present in bioactive natural products

Published:2018 Issue:9 Volume:16 Page:1557-1580
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Montaña Ángel M.¹²³⁴⁵^ORCID,Ponzano Stefano⁶⁷⁸,Sanasi Maria-Filomena⁹¹⁰¹¹,Kociok-Köhn Gabriele¹²¹³¹⁴⁸

Affiliation:

1. Industrial and Applied Organic Chemistry Research Unity

2. Department of Inorganic and Organic Chemistry

3. Universidad de Barcelona

4. 08028-Barcelona

5. Spain

6. European Medicines Agency

7. London E14 5EU

8. UK

9. Agenzia Italiana del Farmaco

10. 181 - 00187 Roma

11. Italy

12. Department of Chemistry

13. University of Bath

14. Bath

Abstract

Development of a versatile and scalable synthetic method of the 10-oxabicyclo[5.2.1]decane framework present in bioactive natural products. The evaluation of the anticancer activity of the synthesized compounds against leukaemia showed a promising activity.

Funder

Ministerio de Economía y Competitividad

Universitat de Barcelona

Generalitat de Catalunya

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB00194D

Reference236 articles.

1. Biotransformation of (4E,8R)-Caryophyll-4(5)-en-8-ol by Botrytis cinerea

2. Potential Antitumor Agents. XVII. Physalin B and 25,26-Epidihydrophysalin C From Witheringia coccoloboides

3. Preliminary Investigation of Structure-Activity Relationship of Cytotoxic Physalins

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