Electrochemically enabled functionalization of indoles or anilines for the synthesis of hexafluoroisopropoxy indole and aniline derivatives

Author:

Mo Zu-Yu1234,Wang Xin-Yu1234,Zhang Yu-Zhen1234,Yang Li5678,Tang Hai-Tao1234ORCID,Pan Ying-Ming1234ORCID

Affiliation:

1. Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources

2. School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University

3. Guilin 541004

4. People's Republic of China

5. Guangxi Key Laboratory of Special Non-wood Forest Cultivation and Utilization

6. Guangxi Zhuang Autonomous Region Forestry Research Institute

7. Nanning

8. P. R. of China

Abstract

We have developed an efficient electrochemical method for selective functionalization of N-acetylindole or aniline derivatives with hexafluoroisopropanol to obtain a series of hexafluoroisopropoxy indoles and anilines.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangxi Province

Science and Technology Major Project of Guangxi

National College Students Innovation and Entrepreneurship Training Program

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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