Thinned young apple polyphenols may prevent neuronal apoptosis by up-regulating 5-hydroxymethylcytosine in the cerebral cortex of high-fat diet-induced diabetic mice-Reference-Cited by-同舟云学术

Thinned young apple polyphenols may prevent neuronal apoptosis by up-regulating 5-hydroxymethylcytosine in the cerebral cortex of high-fat diet-induced diabetic mice

Published:2023 Issue:7 Volume:14 Page:3279-3289
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Ma Qingqing¹²,Gao Jing¹^ORCID,Fan Qiang¹,Yang Tao¹,Zhao Zhuang¹,Zhang Shuangxi¹,Hu Ranrui¹,Cui Li¹,Liang Bing¹³,Xie Xiuying¹⁴,Liu Jiankang¹⁵,Long Jiangang¹

Affiliation:

1. Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong, University, Xi'an, China

2. Central Laboratory, Guizhou Aerospace Hospital, Zunyi, China

3. The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China

4. The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

5. School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao, China

Abstract

TYAPs maintain the TCA cycle and mitochondrial homeostasis to activate TET2 in the cerebral cortex. TYAPs improve diabetes-induced neuronal apoptosis through restoring the 5hmC level, which is mediated by the up-regulation and activation of TET2.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D2FO03281C

Reference38 articles.

1. Diabetes mellitus and risks of cognitive impairment and dementia: A systematic review and meta-analysis of 144 prospective studies

2. Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications

3. Downregulation of the DNA 5-hydroxymethylcytosine is involved in mitochondrial dysfunction and neuronal impairment in high fat diet-induced diabetic mice

4. 5-Hydroxymethylcytosines in Circulating Cell-Free DNA Reveal Vascular Complications of Type 2 Diabetes

5. Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer’s disease

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