Identification of on- and off-pathway oligomers in amyloid fibril formation-Reference-Cited by-同舟云学术

Identification of on- and off-pathway oligomers in amyloid fibril formation

Published:2020 Issue:24 Volume:11 Page:6236-6247
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Dear Alexander J.¹²³⁴⁵^ORCID,Meisl Georg¹²³⁴^ORCID,Šarić Anđela⁶⁷⁸⁹⁴^ORCID,Michaels Thomas C. T.¹²³⁴¹⁰^ORCID,Kjaergaard Magnus¹¹¹²¹³¹⁴^ORCID,Linse Sara⁵¹⁵¹⁶¹⁷^ORCID,Knowles Tuomas P. J.¹²³⁴¹⁸^ORCID

Affiliation:

1. Department of Chemistry

2. University of Cambridge

3. Cambridge CB2 1EW

4. UK

5. Department of Biochemistry and Structural Biology

6. Department of Physics and Astronomy

7. Institute for the Physics of Living Systems

8. University College London

9. London WC1E 6BT

10. Paulson School of Engineering and Applied Sciences

11. Department of Molecular Biology and Genetics

12. Aarhus University

13. DK-8000 Aarhus C

14. Denmark

15. Lund Univerisity

16. SE22100 Lund

17. Sweden

18. Cavendish Laboratory

Abstract

A general non-binary definition for on- and off-pathway intermediates is developed, enabling comparison of amyloid oligomers' contributions to fibril formation.

Funder

Biotechnology and Biological Sciences Research Council

FP7 Ideas: European Research Council

Academy of Medical Sciences

Frances and Augustus Newman Foundation

Royal Society

Sidney Sussex College, University of Cambridge

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Vetenskapsrådet

Lundbeckfonden

Wellcome Trust

Novo Nordisk Fonden