Chinese chestnut shell polyphenol extract regulates the JAK2/STAT3 pathway to alleviate high-fat diet-induced, leptin-resistant obesity in mice-Reference-Cited by-同舟云学术

Chinese chestnut shell polyphenol extract regulates the JAK2/STAT3 pathway to alleviate high-fat diet-induced, leptin-resistant obesity in mice

Published:2023 Issue:10 Volume:14 Page:4807-4823
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Liu Suwen¹²^ORCID,Jiang Wenhong²³,Liu Chang¹,Guo Shuo¹,Wang Hao⁴^ORCID,Chang Xuedong¹²

Affiliation:

1. Engineering Research Center of Chestnut Industry Technology of Ministry of Education, Hebei Key Laboratory of Active Components and Functions in Natural Products, College of Food Science & Technology, Hebei Normal University of Science and Technology, Qinhuangdao, Hebei 066004, China

2. Hebei Yanshan Special Industrial Technology Research Institute, Qinhuangdao, Hebei 066004, China

3. Cofco Great Wall Wine (Ningxia) Co., Ltd, Yinchuan, Ningxia, 750100, China

4. State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology (TUST), Tianjin 300457, China

Abstract

Chinese chestnut shell polyphenol (CSP) reduce inflammation and increase antioxidant capacity, and activating the LEPR-JAK2/STAT3-PTP1B-SOCS-3 signal transduction pathway to alleviate high-fat diet–induced, leptin-resistant obesity in mice.

Funder

Ministry of Education of the People's Republic of China

Hebei Provincial Department of Bureau of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D3FO00604B

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