A targeted covalent small molecule inhibitor of HIV-1 fusion-Reference-Cited by-同舟云学术

A targeted covalent small molecule inhibitor of HIV-1 fusion

Published:2021 Issue:37 Volume:57 Page:4528-4531
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Zhou Guangyan¹²³⁴⁵,He Li¹²³⁴⁵,Li Kathy H.⁶⁷⁸⁹,Pedroso Cássio C. S.¹⁰¹¹¹²¹³¹⁴^ORCID,Gochin Miriam¹²³⁴⁵^ORCID

Affiliation:

1. Department of Basic Sciences

2. Touro University California

3. 1310 Club Drive

4. Mare Island

5. Vallejo

6. Department of Pharmaceutical Chemistry

7. UCSF School of Pharmacy

8. San Francisco

9. USA

10. Lawrence Berkeley National Laboratory

11. The Molecular Foundry

12. 1 Cyclotron Road

13. 67R5114

14. Berkeley

Abstract

Formation of a covalent bond with a conserved lysine in the hydrophobic pocket of HIV-1 gp41 boosted antiviral activity of a small molecule inhibitor.

Funder

National Institute of Allergy and Infectious Diseases

National Institutes of Health

Touro University California

Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

Office of Science

Basic Energy Sciences

U.S. Department of Energy

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D1CC01013A

Reference37 articles.

1. Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target

2. Development of HIV-1 Fusion Inhibitors Targeting gp41

3. Discovery of Small Molecule Fusion Inhibitors Targeting HIV-1 gp41

4. N-Substituted Pyrrole Derivative 12m Inhibits HIV-1 Entry by Targeting Gp41 of HIV-1 Envelope Glycoprotein

5. Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Structure and Interactions of HIV-1 gp41 CHR-NHR Reverse Hairpin Constructs Reveal Molecular Determinants of Antiviral Activity;Journal of Molecular Biology;2024-08

2. Targeting a Conserved Lysine in the Hydrophobic Pocket of HIV-1 gp41 Improves Small Molecule Antiviral Activity;Viruses;2022-12-02

3. The Synthesis of 2,2-BIS(1-INDOL-3-YL)Acenaphthylene-1(2)-Ones Using Nanocatalysis: Fluorescent Sensing for Cu²⁺ Ions;Ecological Chemistry and Engineering S;2022-12-01

4. Novel 2-alkylthio-1-benzylimidazole-5-carboxylic Acid Derivatives Targeting Gp41: Design, Synthesis, and In Vitro Anti-HIV Activity Evaluation;Current HIV Research;2022-09