Substituted kynurenic acid derivatives as fluorophore-based probes for <scp>d</scp>- and <scp>l</scp>-amino acid oxidase assays and their <i>in vitro</i> application in eels-Reference-Cited by-同舟云学术

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Substituted kynurenic acid derivatives as fluorophore-based probes for d- and l-amino acid oxidase assays and their in vitro application in eels

Published:2023 Issue:23 Volume:148 Page:5991-6000
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Sakamoto Tatsuya¹,Onozato Mayu¹,Sugasawa Hiroshi¹,Fukushima Takeshi¹^ORCID

Affiliation:

1. Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi-shi, Chiba 274-8510, Japan

Abstract

Fluorescent probes, 2-MePh-d-KYN and 2-MePh-l-KYN, for detecting d- and l-amino acid oxidase activity, were newly developed respectively. The 2-MePh-d-KYN was successfully applied to detect d-amino acid oxidase activity in eel liver and kidney.

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/AN/D3AN01325A

Reference59 articles.

1. Kynurenine pathway and human systems

2. Role of d -amino acid oxidase in the production of kynurenine pathway metabolites from d -tryptophan in mice

3. The kynurenine pathway in schizophrenia and bipolar disorder

4. Fluorimetric assay for D-amino acid oxidase activity in rat brain homogenate by using D-kynurenine as a substrate

5. Human D-Amino Acid Oxidase: Structure, Function, and Regulation

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