A sensitive and selective liquid chromatography mass spectrometry method for simultaneous estimation of anti-diabetic drugs inhibiting DPP-4 enzyme in human plasma: overcoming challenges associated with low recovery and sensitivity-Reference-Cited by-同舟云学术

A sensitive and selective liquid chromatography mass spectrometry method for simultaneous estimation of anti-diabetic drugs inhibiting DPP-4 enzyme in human plasma: overcoming challenges associated with low recovery and sensitivity

Published:2015 Issue:15 Volume:7 Page:6198-6206
ISSN:1759-9660
Container-title:Analytical Methods
language:en
Short-container-title:Anal. Methods

Author:

Shantikumar S.¹²³⁴,Satheeshkumar N.¹²³⁴,Prasanth B.¹²³⁴,Lingesh A.¹²³⁴,Paul David¹²³⁴,Srinivas R.⁵⁶⁷⁴

Affiliation:

1. Department of Pharmaceutical Analysis

2. National Institute of Pharmaceutical Education and Research, Hyderabad (NIPER-H)

3. Hyderabad 500037

4. India

5. National Center for Mass Spectrometry

6. Indian Institute of Chemical Technology

7. Hyderabad 500607

Abstract

A simple and sensitive LC-QTOF/MS method was developed and validated to measure the human plasma concentrations of five gliptins.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/AY/C5AY00342C

Reference16 articles.

1. DPP-4 inhibitors

2. Dipeptidyl-Peptidase IV from Bench to Bedside: An Update on Structural Properties, Functions, and Clinical Aspects of the Enzyme DPP IV

3. DPP-4 inhibitors and their potential role in the management of type 2 diabetes

4. Novel therapeutics for type 2 diabetes: Incretin hormone mimetics (glucagon-like peptide-1 receptor agonists) and dipeptidyl peptidase-4 inhibitors

5. Quantitative/qualitative analysis using LC–HRMS: the fundamental step forward for clinical laboratories and clinical practice

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