Targeted delivery of pharmacological chaperones for Gaucher disease to macrophages by a mannosylated cyclodextrin carrier

Author:

Rodríguez-Lavado Julio1234,de la Mata Mario567,Jiménez-Blanco José L.1234,García-Moreno M. Isabel1234,Benito Juan M.8910,Díaz-Quintana Antonio11910,Sánchez-Alcázar José A.567,Higaki Katsumi1213141516,Nanba Eiji1213141516,Ohno Kousaku1718141516,Suzuki Yoshiyuki1920,Ortiz Mellet Carmen1234,García Fernández José M.8910

Affiliation:

1. Dept. Química Orgánica

2. Facultad de Química

3. Universidad de Sevilla

4. 41012 Sevilla, Spain

5. Centro Andaluz de Biología del Desarrollo (CABD)

6. CSIC – Universidad Pablo de Olavide

7. 41013 Sevilla, Spain

8. Instituto de Investigaciones Químicas (IIQ)

9. CSIC – Universidad de Sevilla

10. 41092 Sevilla, Spain

11. Instituto de Bioquímica Vegetal y Fotosíntesis (IBVF)

12. Division of Functional Genomics

13. Research Center for Bioscience and Technology

14. Faculty of Medicine

15. Tottori University

16. Yonago, Japan

17. Division of Child Neurology

18. Institute of Neurological Sciences

19. Tokyo Metropolitan Institute of Medical Science

20. Tokyo 156-0057, Japan

Abstract

Efficient delivery of pharmacological chaperones for Gaucher disease to macrophages has been achieved.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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