Development of trisubstituted thiophene-3-arboxamide selenide derivatives as novel EGFR kinase inhibitors with cytotoxic activity-Reference-Cited by-同舟云学术

Development of trisubstituted thiophene-3-arboxamide selenide derivatives as novel EGFR kinase inhibitors with cytotoxic activity

Published:2023 Issue:12 Volume:14 Page:2677-2698
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Makhal Priyanka N.¹^ORCID,Sood Anika²,Shaikh Arbaz Sujat¹^ORCID,Dayare Lahu N.¹,Khatri Dharmendra Kumar²^ORCID,Rao Kaki Venkata¹^ORCID

Affiliation:

1. Department of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad-500037, India

2. Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad-500037, India

Abstract

Selenides of substituted thiophene-3-carboxamide derivatives are designed and synthesized to explore their antiproliferative potential with EGFR inhibition. The excellent in vitro results present a novel hit molecule with EGFR kinase inhibition (nM).

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00403A

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