Alkylation of isatins with trichloroacetimidates-Reference-Cited by-同舟云学术

Alkylation of isatins with trichloroacetimidates

Published:2022 Issue:10 Volume:20 Page:2131-2136
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Mate Nilamber A.¹^ORCID,Meador Rowan I. L.¹^ORCID,Joshi Bhaskar D.¹^ORCID,Chisholm John D.¹^ORCID

Affiliation:

1. Department of Chemistry, Syracuse University, 1-014 Center for Science and Technology, Syracuse, NY 13244, USA

Abstract

N-Alkylation or O-alkylation of isatins can be achieved utilizing trichloroacetimidate electrophiles with the major product being controlled by solvent effects. These reactions provide access to N-alkyl isatins, versatile scaffolds which are often employed in synthesis.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00127F

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