Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above-Reference-Cited by-同舟云学术

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Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above

Published:2018 Issue:39 Volume:9 Page:7681-7687
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Walsh Sarah¹²³⁴⁵^ORCID,El-Sagheer Afaf Helmy¹²³⁴⁶^ORCID,Brown Tom¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Oxford

3. Oxford

4. UK

5. ATDBio Ltd.

6. Chemistry Branch

Abstract

Multiple additions of thiazole orange forms TOTFO probes stable for dsDNA detection and also expands the triplex target range.

Funder

Biotechnology and Biological Sciences Research Council

H2020 Marie Skłodowska-Curie Actions

Horizon 2020 Framework Programme

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/SC/C8SC02418A

Reference44 articles.

1. Sequence-Specific Cleavage of Double Helical DNA by Triple Helix Formation

2. The structure of crystals containing a hydrogen-bonded complex of 1-methylthymine and 9-methyladenine

3. Specificity of the three-stranded complex formation between double-stranded DNA and single-stranded RNA containing repeating nucleotide sequences

4. Site-specific inhibition ofEcoRI restriction/modification enzymes by a DNA triple helix

5. An efficient antigene activity and antiproliferative effect by targeting the Bcl-2 or survivin gene with triplex forming oligonucleotides containing a W-shaped nucleoside analogue (WNA-βT)

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1. Functionalizing DNA Origami by Triplex-Directed Site-Specific Photo-Cross-Linking;Journal of the American Chemical Society;2024-05-02

2. Thiazole orange-carboplatin triplex-forming oligonucleotide (TFO) combination probes enhance targeted DNA crosslinking;RSC Medicinal Chemistry;2024

3. Recent Advancements in Development and Therapeutic Applications of Genome-Targeting Triplex-Forming Oligonucleotides and Peptide Nucleic Acids;Pharmaceutics;2023-10-23

4. Polarity-Specific and Pyrimidine-over-Purine Adaptive Triplex DNA Recognition by a Near-Infrared Fluorogenic Molecular Rotor;Analytical Chemistry;2023-10-03

5. Folding Double‐Stranded DNA into Designed Shapes with Triplex‐Forming Oligonucleotides;Advanced Materials;2023-07-27

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