Efficient synthesis of tetrahydronaphthalene- or isochroman-fused spirooxindoles using tandem reactions-Reference-Cited by-同舟云学术

Efficient synthesis of tetrahydronaphthalene- or isochroman-fused spirooxindoles using tandem reactions

Published:2015 Issue:107 Volume:5 Page:88272-88276
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Wang Biao¹²³⁴⁵,Leng Hai-Jun⁶⁷³⁴⁵,Yang Xue-Yuan¹²³⁴⁵,Han Bo¹²³⁴⁵,Rao Chao-Long⁶⁷³⁴⁵,Liu Li⁶⁷³⁴⁵,Peng Cheng¹²³⁴⁵,Huang Wei¹²³⁴⁵

Affiliation:

1. State Key Laboratory Breeding Base of Systematic Research

2. Development and Utilization of Chinese Medicine Resources

3. Chengdu University of Traditional Chinese Medicine

4. Chengdu 611137

5. China

6. Ministry of Education Key Laboratory of Standardization of Chinese Medicine

7. School of Pharmacy

Abstract

The cascade reaction involving a Michael–aldol or vinylogous Henry-acetalization relay is described. We have used the cascade reaction to assemble tetrahydronaphthalene- or isochroman-fused spirooxindoles and other drug-like spirocyclic scaffolds.

Funder

Foundation for the Author of National Excellent Doctoral Dissertation of the People's Republic of China

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA15735H

Reference59 articles.

1. Induction of intrinsic apoptosis pathway in colon cancer HCT-116 cells by novel 2-substituted-5,6,7,8-tetrahydronaphthalene derivatives

2. Brain-Penetrant Tetrahydronaphthalene Thromboxane A2-Prostanoid (TP) Receptor Antagonists as Prototype Therapeutics for Alzheimer’s Disease

3. Synthesis of Tetrahydronaphthalene Lignan Esters by Intramolecular Cyclization of Ethyl p-Azidophenyl-2-phenylalkanoates and Evaluation of the Growth Inhibition of Human Tumor Cell Lines

4. Antimicrobial Activities of Some Tetrahydronaphthalene-Benzimidazole Derivatives

5. Dissociated Nonsteroidal Glucocorticoid Receptor Modulators; Discovery of the Agonist Trigger in a Tetrahydronaphthalene−Benzoxazine Series

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