Sequence controlled secondary structure is important for the site-selectivity of lanthipeptide cyclization-Reference-Cited by-同舟云学术

Sequence controlled secondary structure is important for the site-selectivity of lanthipeptide cyclization

Published:2023 Issue:25 Volume:14 Page:6904-6914
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Mi Xuenan¹^ORCID,Desormeaux Emily K.²^ORCID,Le Tung T.²^ORCID,van der Donk Wilfred A.²^ORCID,Shukla Diwakar¹³⁴^ORCID

Affiliation:

1. Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA

2. Department of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA

3. Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA

4. Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA

Abstract

We utilize molecular dynamic simulation to demonstrate that the substrate core peptide sequence plays an important role in controlling the site-selectivity of lanthipeptides.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D2SC06546K

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