4′-C-Trifluoromethyl modified oligodeoxynucleotides: synthesis, biochemical studies, and cellular uptake properties-Reference-Cited by-同舟云学术

4′-C-Trifluoromethyl modified oligodeoxynucleotides: synthesis, biochemical studies, and cellular uptake properties

Published:2019 Issue:22 Volume:17 Page:5550-5560
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zhou Yifei¹²³⁴⁵,Zang Chuanlong¹²³⁴⁵,Wang Huawei¹²³⁴⁵,Li Jiajun¹²³⁴⁵,Cui Zenghui¹²³⁴⁵,Li Qiang¹²³⁴⁵,Guo Fengmin¹²³⁴⁵,Yan Zhiguo⁶⁷⁸⁹¹⁰,Wen Xin¹²³⁴⁵,Xi Zhen¹²³⁴⁵,Zhou Chuanzheng¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology

2. College of Chemistry

3. Nankai University

4. Tianjin 300071

5. China

6. Key Laboratory for Green Chemical Process of Ministry of Education

7. Hubei Key Laboratory of Novel Chemical Reactor and Green Chemical Technology

8. School of Chemical Engineering and Pharmacy

9. Wuhan Institute of Technology

10. Wuhan 430073

Abstract

Introducing a 4′-C-trifluoromethyl (4′-CF₃) modification into oligodeoxynucleotides (ODNs) leads to improved nuclease resistance and increased cell permeability.

Funder

National Natural Science Foundation of China

National Basic Research Program of China

Fundamental Research Funds for the Central Universities

Nankai University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB00765B

Reference60 articles.