Application of twin screw extrusion to the manufacture of cocrystals: scale-up of AMG 517–sorbic acid cocrystal production-Reference-Cited by-同舟云学术

Application of twin screw extrusion to the manufacture of cocrystals: scale-up of AMG 517–sorbic acid cocrystal production

Published:2014 Issue: Volume:170 Page:235-249
ISSN:1359-6640
Container-title:Faraday Discuss.
language:en
Short-container-title:Faraday Discuss.

Author:

Daurio Dominick¹²³,Nagapudi Karthik¹²³,Li Lan¹²³,Quan Peter¹²³,Nunez Fernando-Alvarez¹²³

Affiliation:

1. Amgen Inc.

2. Small Molecule Process & Product Development

3. Thousand Oaks, USA

Abstract

The application of twin screw extrusion (TSE) in the scale-up of cocrystal production was investigated by using AMG 517–sorbic acid as a model system. Extrusion parameters that influenced conversion to the cocrystal such as temperature, feed rate and screw speed were investigated. Extent of conversion to the cocrystal was found to have a strong dependence on temperature and a moderate dependence on feed rate and screw speed. Cocrystals made by the TSE process were found to have superior mechanical properties than solution grown cocrystals. Additionally, moving to a TSE process eliminated the need for solvent.

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/FD/C3FD00153A

Reference27 articles.

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5. Saccharin Salts of Active Pharmaceutical Ingredients, Their Crystal Structures, and Increased Water Solubilities

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