Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently
Author:
Affiliation:
1. Manchester Institute of Biotechnology
2. The University of Manchester
3. Manchester M1 7DN
4. UK
5. School of Chemistry
6. Centre for Synthetic Biology of Fine and Speciality Chemicals (SYNBIOCHEM)
Abstract
Improving enzymes by directed evolution requires the navigation of very large search spaces; we survey how to do this intelligently.
Funder
Biotechnology and Biological Sciences Research Council
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/CS/C4CS00351A
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