Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently
Author:
Affiliation:
1. Manchester Institute of Biotechnology
2. The University of Manchester
3. Manchester M1 7DN
4. UK
5. School of Chemistry
6. Centre for Synthetic Biology of Fine and Speciality Chemicals (SYNBIOCHEM)
Abstract
Improving enzymes by directed evolution requires the navigation of very large search spaces; we survey how to do this intelligently.
Funder
Biotechnology and Biological Sciences Research Council
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/CS/C4CS00351A
Reference1345 articles.
1. Scientific discovery as a combinatorial optimisation problem: How best to navigate the landscape of possible experiments?
2. Phylogenetic analysis of DNA sequences, ed. M. M. Miyamoto and J. Cracraft, Oxford University Press, Oxford, 1991
3. R. D. M. Page and E. C.Holmes, Molecular evolution: a phylogenetic approach, Blackwell Science, Oxford, 1998
4. Evolutionary biochemistry: revealing the historical and physical causes of protein properties
5. One-step assembly in yeast of 25 overlapping DNA fragments to form a complete synthetic Mycoplasma genitalium genome
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