The anti-hepatocellular carcinoma effects of polysaccharides from Ganoderma lucidum by regulating macrophage polarization via the MAPK/NF-κB signaling pathway

Author:

Li Guo-li12ORCID,Tang Jia-feng12,Tan Wen-li2,Zhang Tao32,Zeng Di1,Zhao Shuang1,Ran Jian-hua3,Li Jing1,Wang Ya-ping1,Chen Di-long12

Affiliation:

1. Lab of Stem Cell and Tissue Engineering, Department of Histology and Embryology, Chongqing Medical University, Chongqing, PR China

2. Chongqing Key Laboratory of Development and Utilization of Genuine Medicinal Materials in Three Gorges Reservoir Area, Chongqing Three Gorges Medical College, Chongqing, PR China

3. Neuroscience Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, PR China

Abstract

 Ganoderma lucidum polysaccharide (GLPS) can inhibit hepatocellular carcinoma (HCC). But the mechanism of GLPS's effect is little known. This data showed that GLPS can regulate MAPK/NF-κB signaling responsible for M1 polarization in anti-HCC.

Funder

Chongqing Municipal Education Commission Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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