Development of potent tripodal G-quadruplex DNA binders and their efficient delivery to cancer cells by aptamer functionalised liposomes-Reference-Cited by-同舟云学术

Development of potent tripodal G-quadruplex DNA binders and their efficient delivery to cancer cells by aptamer functionalised liposomes

Published:2023 Issue:5 Volume:21 Page:1000-1007
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Pont Isabel¹,Galiana-Roselló Cristina¹,Sabater-Arcis Maria²³⁴,Bargiela Ariadna⁵,Frías Juan Carlos⁶,Albelda M. Teresa¹,González-García Jorge¹^ORCID,García-España Enrique¹^ORCID

Affiliation:

1. Instituto de Ciencia Molecular (ICMol), Departamento de Química Inorgánica, Universidad de Valencia, Catedrático José Beltrán 2, 46980, Paterna, Spain

2. Translational Genomics Group, Incliva Health Research Institute, Valencia, Spain

3. Interdisciplinary Research Structure for Biotechnology and Biomedicine (ERI BIOTECMED), University of Valencia, Valencia, Spain

4. CIPF-INCLIVA Joint Unit, Valencia, Spain

5. Neuromuscular Research Unit, Neurology Department, Hospital La Fe, Instituto de Investigación Sanitaria La Fe (IISLAFE), Valencia, Spain

6. Department of Biomedical Sciences, CEU Cardenal Herrera University, Ramón y Cajal s/n, 46115 Alfara del Patriarca, Spain

Abstract

Trisubstituted TPA/TPB-based ligands containing linear and macrocyclic polyamines show strong G-quadruplex stabilisation and selectivity over duplex DNA. Encapsulation in AS1411 aptamer-targeted liposomes dramatically increases their cytotoxicity.

Funder

Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital, Generalitat Valenciana

Ministerio de Ciencia e Innovación

European Cooperation in Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D2OB01911F

Reference64 articles.

1. A comprehensive map of molecular drug targets

2. Epigenetic modifications as therapeutic targets

3. Quadruplex Nucleic Acids as Novel Therapeutic Targets

4. The Structure and Function of DNA G-Quadruplexes

5. G-Quadruplexes in Neurobiology and Virology: Functional Roles and Potential Therapeutic Approaches

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