Targeting the tubulin C-terminal tail by charged small molecules-Reference-Cited by-同舟云学术

Targeting the tubulin C-terminal tail by charged small molecules

Published:2023 Issue:1 Volume:21 Page:153-162
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Li Shuo¹^ORCID,Mori Mattia²,Yang Mingyan¹^ORCID,Elfazazi Soumia³^ORCID,Hortigüela Rafael³,Chan Peter⁴,Feng Xinyue⁵,Risinger April⁴^ORCID,Yang Zhiyou⁵,Oliva María Ángela³,Fernando Díaz J.³^ORCID,Fang Wei-Shuo¹^ORCID

Affiliation:

1. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines & MHC Key Laboratory of Biosynthesis of Natural Products, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 2A Nan Wei Road, Beijing 100050, China

2. Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, Siena 53100, Italy

3. Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, Madrid 28040, Spain

4. Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA

5. College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution, Zhanjiang 524088, China

Abstract

A series of linear and cyclic peptides bearing triple arginines were synthesized to bind to the tubulin C-terminal tail, providing a starting point to target this versatile yet undruggable site.

Funder

Ministerio de Ciencia e Innovación

Natural Science Foundation of Guangdong Province

Max and Minnie Tomerlin Voelcker Fund

European Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D2OB01910H

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