Perforalactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr.

Author:

Liu Shuai12,Zhang Cui-Shan12,Ran Xiao-Qian32ORCID,Tang Xiao-Han1,Guo Ya-Rong4ORCID,Yan Ying5,Yao Yong-Gang326,Hao Xiao-Jiang1ORCID,Luo Rong-Can23ORCID,Di Ying-Tong12ORCID

Affiliation:

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China

2. Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China

3. Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650204, China

4. School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China

5. Guizhou Chemical Drug Research and Development Engineering Technical Center, Guizhou Medicinal University, Guiyang 550004, China

6. CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China

Abstract

Two new quassinoids, perforalactones D and E, from Harrisonia perforata, could promote the expression of lysosomal genes and induce lysosomal biogenesis.

Funder

Chinese Academy of Sciences

Youth Innovation Promotion Association of the Chinese Academy of Sciences

Yunnan Provincial Science and Technology Department

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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