Investigation of the remote acyl group participation in glycosylation from conformational perspectives by using trichloroacetimidate as the acetyl surrogate-Reference-Cited by-同舟云学术

Investigation of the remote acyl group participation in glycosylation from conformational perspectives by using trichloroacetimidate as the acetyl surrogate

Published:2020 Issue:13 Volume:7 Page:1606-1615
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Xu Ke¹²³⁴⁵,Man Qingmin⁶⁷⁵⁸⁹,Zhang Yang¹²³⁴⁵,Guo Jia¹²³⁴⁵,Liu Yichu¹²³⁴⁵,Fu Zunyun¹⁰¹¹⁵⁸⁹,Zhu Yueyue¹²³⁴⁵,Li Yingxia¹²³⁴⁵,Zheng Mingyue⁸⁹¹²⁴⁵^ORCID,Ding Ning¹²³⁴⁵^ORCID

Affiliation:

1. Department of Medicinal Chemistry

2. School of Pharmacy

3. Fudan University

4. Shanghai 201203

5. China

6. University of Science and Technology of China

7. Hefei

8. State Key Laboratory of Drug Research

9. Shanghai Institute of Materia Medica

10. Nanjing University of Chinese Medicine

11. Jiangsu

12. Chinese Academy of Sciences

Abstract

The remote acyl group participation in glycosylation was studied by using trichloroacetimidate as the acetyl surrogate. The bridging participation intermediates were systematically trapped, and DFT calculations were applied to explain the results.

Funder

National Key New Drug Creation and Manufacturing Program, Ministry of Science and Technology

National Natural Science Foundation of China

Chinese Academy of Sciences

Shanghai Municipal Human Resources and Social Security Bureau

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/QO/D0QO00363H

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