Synthesis of novel fatty acid 3,4-dihydropyrimidin-2-(1<i>H</i>)-one and antitumoral activity against breast and gastric cancer cells-Reference-Cited by-同舟云学术

Synthesis of novel fatty acid 3,4-dihydropyrimidin-2-(1H)-one and antitumoral activity against breast and gastric cancer cells

Published:2024 Issue:32 Volume:14 Page:22981-22987
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Rios E. A. M.¹,Dea C. M.¹,dos Santos E. R. F. B.¹,D'Oca M. G. M.²,Rampon D. S.¹^ORCID,Nachtigall F. M.³,Santos L. S.⁴^ORCID,Guzman L.⁵,Moore-Carrasco R.⁵,Rebolledo-Mira D.⁶,D'Oca. C. R. M.¹^ORCID

Affiliation:

1. Laboratory of Polymers and Catalysis (LAPOCA), Department of Chemistry, Federal University of Paraná – UFPR, P. O. Box 19061, Curitiba, PR, 81531-990, Brazil

2. Kolbe's Laboratory of Organic Synthesis, Department of Chemistry, Federal University of Paraná – UFPR, P. O. Box 19032, Curitiba, PR, 81531-990, Brazil

3. Instituto de Ciencias Aplicadas – Universidad Autónoma de Chile, Talca 3467987, Chile

4. Laboratory of Asymmetric Synthesis, Chemistry Institute of Natural Resources, Universidad de Talca, Talca 3460000, Chile

5. Departamento de Bioquímica Clínica e Inmunohematología, Facultad de Ciencias de la Salud, Universidad de Talca, P.O. Box 747, Talca 3460000, Chile

6. Center for Medical Research, School of Medicine, University of Talca, Talca 3460000, Chile

Abstract

Monastrol is a cell-permeable molecule recognized as an inhibitor of mitotic kinesin Eg5, that is over-expressed in tumor cells and is a very promising target for developing new drugs for cancer disease.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA03292F

Reference21 articles.

1. Advances in the discovery of DHPMs as Eg5 inhibitors for the management of breast cancer and glioblastoma: A review

2. International Agency for Research on Cancer , available on https://www.iarc.who.int/ [accessed on March, 15th, 2024]

3. Walking on two heads: the many talents of kinesin

4. Kinesins and cancer

5. Ueber Aldehyduramide des Acetessigäthers