Structural and stereochemical diversity in prenylated indole alkaloids containing the bicyclo[2.2.2]diazaoctane ring system from marine and terrestrial fungi

Author:

Klas Kimberly R.1234,Kato Hikaru5678,Frisvad Jens C.9101112,Yu Fengan131415164,Newmister Sean A.131415164,Fraley Amy E.131415164,Sherman David H.131415164,Tsukamoto Sachiko5678,Williams Robert M.123417

Affiliation:

1. Department of Chemistry

2. Colorado State University

3. Fort Collins

4. USA

5. Graduate School of Pharmaceutical Sciences

6. Kumamoto University

7. Kumamoto 862-0973

8. Japan

9. Section for Eukaryotic Biotechnology

10. Departments of System Biology

11. Technical University of Denmark

12. Denmark

13. Life Sciences Institute

14. Departments of Medicinal Chemistry, Chemistry, Microbiology & Immunology

15. The University of Michigan

16. Ann Arbor

17. University of Colorado

Abstract

Various fungi of the generaAspergillus,Penicillium, andMalbrancheaproduce prenylated indole alkaloids possessing a bicyclo[2.2.2]diazaoctane ring system.

Funder

Ministry of Education, Culture, Sports, Science and Technology

Nagase Science Technology Foundation

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

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