All-photonic kinase inhibitors: light-controlled release-and-report inhibition-Reference-Cited by-同舟云学术

All-photonic kinase inhibitors: light-controlled release-and-report inhibition

Published:2024 Issue:18 Volume:15 Page:6897-6905
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Fleming Cassandra L.¹²^ORCID,Benitez-Martin Carlos¹^ORCID,Bernson Elin³^ORCID,Xu Yongjin²,Kristenson Linnea⁴,Inghardt Tord⁵^ORCID,Lundbäck Thomas⁶^ORCID,Thorén Fredrik B.⁷^ORCID,Grøtli Morten²^ORCID,Andréasson Joakim¹^ORCID

Affiliation:

1. Department of Chemistry and Chemical Engineering, Physical Chemistry, Chalmers University of Technology, SE-41296, Göteborg, Sweden

2. Department of Chemistry and Molecular Biology, University of Gothenburg, Box 462, SE-40530, Göteborg, Sweden

3. TIMM Laboratory at Sahlgrenska Centre for Cancer Research, Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, SE-41296, Göteborg, Sweden

4. TIMM Laboratory, Sahlgrenska Centre for Cancer Research, Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, SE-41296, Göteborg, Sweden

5. Cardiovascular, Renal and Metabolism, Innovative Medicines and Early Development, AstraZeneca, SE-43183, Mölndal, Sweden

6. Mechanistic and Structural Biology, Discovery Sciences, R&D, AstraZeneca, SE-43183, Mölndal, Sweden

7. TIMM Laboratory, Sahlgrenska Centre for Cancer Research, Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, SE-41296, Göteborg, Sweden

Abstract

An all-photonic method is described, in which (i) the release of an active kinase inhibitor is controlled externally with light; and (ii) fluorescence is employed to report both the release and binding of the inhibitor to its corresponding target.

Funder

Olle Engkvists Stiftelse

Vetenskapsrådet

Carl Tryggers Stiftelse för Vetenskaplig Forskning

H2020 Marie Skłodowska-Curie Actions

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC00390J

Reference45 articles.

1. Light-triggered release of photocaged therapeutics - Where are we now?

2. Genetically Encoding Photocaged Quinone Methide to Multitarget Protein Residues Covalently in Vivo

3. Reversible Control of Protein Localization in Living Cells Using a Photocaged-Photocleavable Chemical Dimerizer

4. Light‐Activatable Photocaged UNC2025 for Triggering TAM Kinase Inhibition in Bladder Cancer

5. Photoswitchable Inhibitors to Optically Control Specific Kinase Activity

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