Revisiting the sparteine surrogate: development of a resolution route to the (−)-sparteine surrogate

Abstract

A multi-gram scale, chromatography-free synthesis of the racemic sparteine surrogate and its resolution via diastereomeric salt formation with (−)-O,O′-di-p-toluoyl-l-tartaric acid is reported. This work solves a key limitation: either enantiomer of the sparteine surrogate can now be readily accessed.