Catalytic enantioselective intramolecular 1,3-dipolar cycloaddition of azomethine ylides with fluorinated dipolarophiles

Author:

Cristóbal Christian1,Gaviña Daniel2,Alonso Inés134ORCID,Ribagorda María13ORCID,Carretero Juan C.134ORCID,del Pozo Carlos2ORCID,Adrio Javier134ORCID

Affiliation:

1. Departamento de Química Orgánica, Facultad de Ciencias, C/Francisco Tomás y Valiente 7, Universidad Autónoma de Madrid, 28049 Madrid, Spain

2. Departamento de Química Orgánica, Universidad de Valencia, E-46100 Burjassot, Spain

3. Institute for Advanced Research in Chemical Sciences (IAdChem), Universidad Autónoma de Madrid, 28049 Madrid, Spain

4. Centro de Innovación en Química Avanzada (ORFEO-CINQA), Spain

Abstract

A copper catalyzed highly diastereo and enantioselective intramolecular 1,3-dipolar cycloaddition for the preparation of fluorinated hexahydrocromenopyrrolidines is reported.

Funder

Ministerio de Ciencia, Innovación y Universidades

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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