Nano-scale imaging of dual stable isotope labeled oxaliplatin in human colon cancer cells reveals the nucleolus as a putative node for therapeutic effect

Author:

Legin Anton A.12345ORCID,Schintlmeister Arno63457ORCID,Sommerfeld Nadine S.12345,Eckhard Margret8345,Theiner Sarah12345ORCID,Reipert Siegfried8345ORCID,Strohhofer Daniel12345,Jakupec Michael A.12345ORCID,Galanski Markus12345ORCID,Wagner Michael63457,Keppler Bernhard K.12345

Affiliation:

1. Institute of Inorganic Chemistry

2. Faculty of Chemistry

3. University of Vienna

4. A-1090 Vienna

5. Austria

6. Research Network “Chemistry Meets Microbiology and Environmental Systems Science”

7. Division of Microbial Ecology

8. Core Facility Cell Imaging and Ultrastructural Research

Abstract

Correlated imaging by means of NanoSIMS and electron microscopy reveals the distribution of stable isotope labeled oxaliplatin in cancer cells.

Funder

Austrian Science Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering

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