Overview of the structure, side effects, and activity assays of l-asparaginase as a therapy drug of acute lymphoblastic leukemia

Author:

Wang Nanxiang1,Ji Wenhui1,Wang Lan1,Wu Wanxia1,Zhang Wei1,Wu Qiong1ORCID,Du Wei1,Bai Hua2,Peng Bo2,Ma Bo3,Li Lin1ORCID

Affiliation:

1. Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University, Nanjing, 211800, China

2. Frontiers Science Center for Flexible Electronics, Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering, Northwestern Polytechnical University, Xi'an, 710072, China

3. School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 211800, China

Abstract

We summarized its structure and mechanism in detail, reviewed the detection approaches, and prospected the development of future detection assays.

Funder

Key Technologies Research and Development Program

Fundamental Research Funds for the Central Universities

National Natural Science Foundation of China

ShanXi Science and Technology Department

Northwestern Polytechnical University

Natural Science Foundation of Ningbo

Shanxi Provincial Key Research and Development Project

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

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