Electro-mechanical coupling directs endothelial activities through intracellular calcium ion deployment

Author:

Li Changhao12,Yu Peng1,Wang Zhengao1,Long Cheng3,Xiao Cairong1,Xing Jun1,Dong Binbin3,Zhai Jinxia1,Zhou Lei1,Zhou Zhengnan1,Wang Yan2,Zhu Wenjun2,Tan Guoxin4,Ning Chengyun1,Zhou Yahong5,Mao Chuanbin67ORCID

Affiliation:

1. School of Material Science and Engineering & National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China

2. Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, 510055, China

3. School of Life Sciences, South China Normal University, Guangzhou 510631, China

4. School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, 510006, China

5. CAS Key Laboratory of Bio-inspired Materials and Interfacial Science, Technical Institute of Physics and Chemistry, Chinese Academy of Science, Beijing 100190, China

6. Department of Biomedical Engineering, The Chinese University of Hong Kong, Sha Tin, Hong Kong SAR, China

7. School of Materials Science & Engineering, Zhejiang University, Hangzhou, 310027, China

Abstract

The use of confined electric fields reveals an analogous electro-mechanical coupling behavior in endothelial cells, which can integrate electrical and mechanical signals to direct the endothelial fate through intracellular calcium ion deployment.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Basic and Applied Basic Research Foundation of Guangdong Province

Guangdong Medical Research Foundation

Changzhou Municipal Science and Technology Bureau

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrical and Electronic Engineering,Process Chemistry and Technology,Mechanics of Materials,General Materials Science

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