In depth analysis of kinase cross screening data to identify chemical starting points for inhibition of the Nek family of kinases
Author:
Affiliation:
1. Structural Genomics Consortium
2. Eshelman School of Pharmacy
3. University of North Carolina at Chapel Hill
4. Chapel Hill
5. 27599 USA
6. Universidade Estadual de Campinas – UNICAMP
7. Campinas
8. 13083 Brazil
Abstract
Potent, selective, and cell active small molecule kinase inhibitors are useful tools to help unravel the complexities of kinase signaling.
Funder
Eshelman Institute for Innovation, University of North Carolina
National Center for Advancing Translational Sciences
Publisher
Royal Society of Chemistry (RSC)
Subject
Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/MD/C7MD00510E
Reference117 articles.
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5. Assessment of Chemical Coverage of Kinome Space and Its Implications for Kinase Drug Discovery
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