Construction of an octosyl acid backbone catalyzed by a radical S-adenosylmethionine enzyme and a phosphatase in the biosynthesis of high-carbon sugar nucleoside antibiotics-Reference-Cited by-同舟云学术

Construction of an octosyl acid backbone catalyzed by a radical S-adenosylmethionine enzyme and a phosphatase in the biosynthesis of high-carbon sugar nucleoside antibiotics

Published:2017 Issue:1 Volume:8 Page:444-451
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

He Nisha¹²³⁴⁵,Wu Pan¹²³⁴⁵,Lei Yongxing⁶⁷⁸⁹¹⁰,Xu Baofu⁶⁷⁸⁹¹⁰,Zhu Xiaochen⁶⁷⁸⁹¹⁰,Xu Gudan¹²³⁴⁵,Gao Yaojie¹²³⁴⁵,Qi Jianzhao¹²³⁴⁵,Deng Zixin¹²³⁴⁵,Tang Gongli¹¹¹²¹⁰¹³¹⁴,Chen Wenqing¹²³⁴⁵,Xiao Youli⁶⁷⁸⁹¹⁰

Affiliation:

1. Key Laboratory of Combinatorial Biosynthesis and Drug Discovery

2. Ministry of Education

3. School of Pharmaceutical Sciences

4. Wuhan University

5. Wuhan 430071

6. CAS Key Laboratory of Synthetic Biology

7. CAS Center for Excellence in Molecular Plant Sciences

8. Institute of Plant Physiology and Ecology

9. Shanghai Institutes for Biological Sciences

10. Chinese Academy of Sciences

11. State Key Laboratory of Bio-organic and Natural Products Chemistry

12. Shanghai Institute of Organic Chemistry

13. Shanghai 200032

14. China

Abstract

This work provides, for the first time, significant in vitro evidence for the biosynthetic origins of octosyl acid through free radical and dephosphorylation enzymatic reactions.

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C6SC01826B

Reference34 articles.

1. Nucleoside antibiotics: Structure, biological activity, and biosynthesis.

2. Natural and engineered biosynthesis of nucleoside antibiotics in Actinomycetes