Application of the anthraquinone drug rhein as an axial ligand in bifunctional Pt(<scp>iv</scp>) complexes to obtain antiproliferative agents against human glioblastoma cells-Reference-Cited by-同舟云学术

Application of the anthraquinone drug rhein as an axial ligand in bifunctional Pt(iv) complexes to obtain antiproliferative agents against human glioblastoma cells

Published:2022 Issue:15 Volume:51 Page:6014-6026
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Gabano Elisabetta¹^ORCID,Gariboldi Marzia Bruna²,Caron Giulia³^ORCID,Ermondi Giuseppe³,Marras Emanuela²,Vallaro Maura³,Ravera Mauro¹^ORCID

Affiliation:

1. Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale, Viale Michel 11, 15121 Alessandria, Italy

2. Dipartimento di Biotecnologie e Scienze della Vita (DBSV), Università dell'Insubria, via Dunant 3, Varese, Italy

3. CASSMedChem, Dipartimento di Biotecnologie Molecolari e Scienze per la Salute, Università di Torino, Via Quarello 15, 10135 Torino, Italy

Abstract

Pt(iv) antitumor prodrugs containing rhein are cytotoxic and cause reduction in the motility of human glioblastoma cells. Physicochemical and computational studies suggest that the complexes may cross the blood–brain barrier.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/DT/D2DT00235C

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