Exploring the synthetic potential of a marine transaminase including discrimination at a remote stereocentre
Author:
Affiliation:
1. School of Chemistry
2. Analytical and Biological Chemistry Research Facility
3. University College Cork
4. Cork
5. Ireland
6. BIOMERIT Research Centre; School of Microbiology
7. T12 K8AF Cork
8. Synthesis and Solid-State Pharmaceutical Centre
Abstract
Transamination from 1-aminotetralins and 1-aminoindanes with differentiation of stereochemistry at both the site of reaction and at a remote stereocentre.
Funder
Irish Research Council
Thermo Fisher Scientific
GlaxoSmithKline
Science Foundation Ireland
Enterprise Ireland
Health Research Board
European Commission
Food Institutional Research Measure
Cystic Fibrosis Foundation
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2021/OB/D0OB01848A
Reference55 articles.
1. Industrial Methods for the Production of Optically Active Intermediates
2. T. C. Nugent , Chiral Amine Synthesis: Methods, Developments and Applications , Wiley-VCH , Weinheim , 2010
3. Expanding the organic toolbox: a guide to integrating biocatalysis in synthesis
4. U. T. Bornscheuer and M.Hohne , in Enzyme Catalysis in Organic Synthesis , ed. K. Drauz , H. Gröger and O. May , Wiley-VCH , Weinheim , 2012 , vol. 19 , pp. 779–820
5. The Industrial Age of Biocatalytic Transamination
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