A mechanistic study on the inhibition of α-chymotrypsin by a macrocyclic peptidomimetic aldehyde-Reference-Cited by-同舟云学术

A mechanistic study on the inhibition of α-chymotrypsin by a macrocyclic peptidomimetic aldehyde

Published:2016 Issue:29 Volume:14 Page:6970-6978
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zhang X.¹²³⁴⁵,Bruning J. B.⁶⁴⁵⁷,George J. H.³⁴⁵⁷,Abell A. D.¹²³⁴⁵

Affiliation:

1. ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP)

2. Institute for Photonics and Advanced Sensing

3. Department of Chemistry

4. The University of Adelaide

5. Adelaide

6. School of Biological Sciences

7. Australia

Abstract

NMR and X-ray crystallography reveals covalent attachment of the macrocyclic aldehyde to serine195 of α-chymotrypsin and that its backbone binds as a β-strand.

Funder

Australian Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01159D

Reference47 articles.

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4. Substrate Shape Determines Specificity of Recognition for HIV-1 Protease

5. Structural Basis for Proteolytic Specificity of the Human Apoptosis-Inducing Granzyme M

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