Reviving old protecting group chemistry for site-selective peptide–protein conjugation-Reference-Cited by-同舟云学术

Reviving old protecting group chemistry for site-selective peptide–protein conjugation

Published:2018 Issue:84 Volume:54 Page:11929-11932
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Gunnoo Smita B.¹²³⁴⁵,Iyer Abhishek¹²³⁴⁵,Vannecke Willem¹²³⁴⁵,Decoene Klaas W.¹²³⁴⁵,Hebbrecht Tim⁶⁷⁸³⁴^ORCID,Gettemans Jan⁶⁷⁸³⁴,Laga Mathias⁹¹⁰¹¹⁵,Loverix Stefan⁹¹⁰¹¹⁵,Lasters Ignace⁹¹⁰¹¹⁵,Madder Annemieke¹²³⁴⁵^ORCID

Affiliation:

1. OBCR Group

2. Dept. of Organic and Macromolecular Chemistry

3. Ghent University

4. Ghent

5. Belgium

6. Nanobody Lab

7. Dept. of Biochemistry

8. Faculty of Medicine and Health Sciences

9. Complix NV

10. Bioville

11. Diepenbeek

Abstract

Unprotected peptides equipped with property enhancing moieties and a Cys(Scm) residue can be site-selectively conjugated to proteins via crossed-disulfide formation.

Funder

Fonds Wetenschappelijk Onderzoek

Bijzonder Onderzoeksfonds

Agentschap Innoveren en Ondernemen

Universiteit Gent

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C8CC06684A

Reference28 articles.

1. Non-immunoglobulin scaffolds: a focus on their targets

2. Bioconjugation – using selective chemistry to enhance the properties of proteins and peptides as therapeutics and carriers

3. Strategies and challenges for the next generation of antibody–drug conjugates

4. Cryptophycins: cytotoxic cyclodepsipeptides with potential for tumor targeting

5. Chemoselective Ligation and Modification Strategies for Peptides and Proteins

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