The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor-Reference-Cited by-同舟云学术

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

Published:2020 Issue:23 Volume:8 Page:6603-6610
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Müller Werner E. G.¹²³⁴^ORCID,Neufurth Meik¹²³⁴,Schepler Hadrian⁵⁶⁷⁴,Wang Shunfeng¹²³⁴,Tolba Emad¹²³⁴^ORCID,Schröder Heinz C.¹²³⁴,Wang Xiaohong¹²³⁴^ORCID

Affiliation:

1. ERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry

2. University Medical Center of the Johannes Gutenberg University

3. 55128 Mainz

4. Germany

5. Department of Dermatology

6. University Clinic Mainz

7. 55131 Mainz

Abstract

The polymer polyphosphate, abundant in blood platelets, blocks the binding of the receptor-binding domain (RBD) of the SARS- spike (S)-protein to the angiotensin-converting enzyme 2 (ACE2) at low concentrations.

Funder

H2020 European Research Council

Bundesministerium für Bildung und Forschung

European Commission

Universitätsmedizin der Johannes Gutenberg-Universität Mainz

Bundesministerium für Wirtschaft und Technologie

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/BM/D0BM01244K

Reference68 articles.

1. EVOLUTION OF THE INNATE AND ADAPTIVE IMMUNE SYSTEMS

2. The amazing innate immune response to influenza A virus infection

3. Pathogen Recognition and Innate Immunity

4. F. Roth-Walter , A. B.Riemer , E.Jensen-Jarolim and H.Stockinger , in Comparative Medicine , ed. E. Jensen-Jarolim , Springer-Press , Wien , 2014 , pp. 219–266

5. Platelet-macrophage partnership in innate immunity and inflammation

Cited by 20 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The dynamic relationship between inorganic polyphosphate and adenosine triphosphate in human non‐small cell lung cancer H1299 cells;FEBS Open Bio;2024-01

2. Unusual specific interaction of RBD with zeolite induces rapid neutralization of SARS-CoV-2;2023-11-07

3. Marine Sponge-Derived Secondary Metabolites Modulate SARS-CoV-2 Entry Mechanisms;Hormone and Metabolic Research;2023-10-04

4. In-vivo functions and regulation of polyphosphate in the vascular system;Current Opinion in Hematology;2023-07-17

5. Platelet-Inspired Nanotherapeutics for Biomedical Applications;ACS Materials Letters;2023-01-09