Selective construction of alkaloid scaffolds by alcohol-based direct and mild aerobic oxidative Pictet–Spengler reactions
Author:
Affiliation:
1. College of Chemistry and Materials Engineering
2. Wenzhou University
3. Wenzhou
4. China
5. School of Chemistry and Chemical Engineering
Abstract
Tetrahydro-β-carboline and β-carboline alkaloid scaffolds can be selectively obtained by direct aerobic oxidative Pictet–Spengler reactions of tryptamines with alcohols using TBN/TEMPO as the catalysts and oxygen as the oxidant under mild conditions.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Zhejiang Province
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB01549K
Reference98 articles.
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4. The Chiral Pool in the Pictet–Spengler Reaction for the Synthesis of β-Carbolines
5. Enantioselective Catalytic Methods for the Elaboration of Chiral Tetrahydro-β-carbolines and Related Scaffolds
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