One-step synthesis of N,N′-substituted 4-imidazolidinones by an isocyanide-based pseudo-five-multicomponent reaction
Author:
Affiliation:
1. Departamento de Química Orgánica
2. Facultad de Ciencias Exactas y Naturales
3. Universidad de Buenos Aires
4. Ciudad Universitaria
5. Ciudad Autónoma de Buenos Aires
Abstract
A pseudo-five-multicomponent reaction involving an isocyanide, a primary amine, two molecules of formaldehyde and water is reported, which gives N,N′-substituted 4-imidazolidinones when trifluoroethanol is used as the solvent.
Funder
Universidad de Buenos Aires
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB02229A
Reference29 articles.
1. Multicomponent Reaction Design in the Quest for Molecular Complexity and Diversity
2. Ugi Reactions with Ammonia Offer Rapid Access to a Wide Range of 5-Aminothiazole and Oxazole Derivatives
3. The Ugi-Smiles and Passerini-Smiles Couplings: A Story About Phenols in Isocyanide-Based Multicomponent Reactions
4. Oxaline, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of tubulin polymerization
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