Leukemia stem cells, direct targeting of CD123 based on the nano-smart polymer PMBN
Author:
Affiliation:
1. Faculty of New Sciences and Technologies
2. University of Tehran
3. Tehran
4. Iran
5. Iran Polymer and Petrochemical Institute
Abstract
Direct targeting of LSCs based on PMBN-IL3 smart nano carrier with incorporated hydrophobic agents PTX and GA-A leads to apoptosis.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA19989E
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1. The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells
2. Elevated expression of IL-3Rα in acute myelogenous leukemia is associated with enhanced blast proliferation, increased cellularity, and poor prognosis
3. Detection, isolation, and stimulation of quiescent primitive leukemic progenitor cells from patients with acute myeloid leukemia (AML)
4. Tumour stem cells and drug resistance
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