The pentafluorosulfanyl group in cannabinoid receptor ligands: synthesis and comparison with trifluoromethyl and tert-butyl analogues-Reference-Cited by-同舟云学术

The pentafluorosulfanyl group in cannabinoid receptor ligands: synthesis and comparison with trifluoromethyl and tert-butyl analogues

Published:2014 Issue:39 Volume:4 Page:20164-20176
ISSN:2046-2069
Container-title:RSC Adv.
language:en
Short-container-title:RSC Adv.

Author:

Altomonte Stefano¹²³⁴,Baillie Gemma L.⁵⁶⁷⁸,Ross Ruth A.⁵⁶⁷⁸,Riley Jennifer⁹¹⁰¹¹,Zanda Matteo¹²³⁴¹²

Affiliation:

1. Kosterlitz Centre for Therapeutics

2. Institute of Medical Sciences and “John Mallard” Scottish PET Centre

3. University of Aberdeen

4. Aberdeen AB25 2ZD, UK

5. Medical Sciences Building

6. University of Toronto

7. 1 King's College Circle

8. Toronto, Canada

9. Drug Discovery Unit

10. University of Dundee

11. Dundee, UK

12. C.N.R.-Istituto di Chimica del Riconoscimento Molecolare

Abstract

Competitive CB₁ receptor antagonists carrying an aromatic SF₅ group in position 3 of a pyrazole ring were synthesised and compared with their CF₃ and tert-butyl analogues. Results confirmed that an aromatic SF₅ group can be used as a bioisosteric analogue of a CF₃ group and possibly of a bulky aliphatic group too.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/RA/C4RA01212G

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