Identification, synthesis and characterization of avanafil process impurities and determination by UPLC-Reference-Cited by-同舟云学术

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Identification, synthesis and characterization of avanafil process impurities and determination by UPLC

Published:2022 Issue:15 Volume:12 Page:9256-9262
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zhao Mengmeng¹²,Wu Xiaoxia¹,Yu Zengda²,Sun Yunkai¹³^ORCID,Liu Zhao²,Yuan Jinqiao²,Liu Hu²,Jin Yiping²

Affiliation:

1. College of Chemistry and Chemical Engineering, University of South China, Hengyang, 421001, China

2. Harvest Pharmaceutical Co., Ltd, Changsha, 410000, China

3. School of Chemistry and Materials Science, Changzhou Institute of Technology, Changzhou, 213022, China

Abstract

Four process-related impurities of avanafil with a content of 0.29–1.63% were detected by the newly developed gradient UPLC.

Funder

Natural Science Foundation of Hunan Province

University of South China

Education Department of Hunan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA01224C

Reference19 articles.

1. Erectile dysfunction

2. Comparative Effectiveness and Safety of Oral Phosphodiesterase Type 5 Inhibitors for Erectile Dysfunction: A Systematic Review and Network Meta-analysis

3. Tolerability and pharmacokinetics of avanafil, a phosphodiesterase type 5 inhibitor: A single- and multiple-dose, double-blind, randomized, placebo-controlled, dose-escalation study in healthy Korean male volunteers

4. Current diagnosis and management of erectile dysfunction

5. Erectile Dysfunction: AUA Guideline

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