Multivalent agents containing 1-substituted 2,3,4-trihydroxyphenyl moieties as novel synthetic polyphenols directed against HIV-1

Author:

Flores Aida12,Camarasa María José12,Pérez-Pérez María Jesús12,San-Félix Ana12,Balzarini Jan345,Quesada Ernesto12

Affiliation:

1. Instituto de Química Médica CSIC

2. 28006 Madrid, Spain

3. Rega Institute for Medical Research

4. KU Leuven

5. B-3000 Leuven, Belgium

Abstract

A series of synthetic polyphenols inspired by the multivalent architecture of naturally-occurring hydrolysable tannins exhibited selective inhibitory activity against HIV-1.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference73 articles.

1. UNAIDS report on the global AIDS epidemic 2013. Published November 18, 2013. http://www.unaids.org/en/media/unaids/contentassets/documents/epidemiology/2013/gr2013/UNAIDS_Global_Report_2013_en.pdf (accessed February 15th, 2014)

2. An up-to-date list of approved drugs against HIV infections is available at http://www.fda.gov (accessed February 15th, 2014)

3. Antiretroviral drugs

4. S. T. Butera , in HIV Chemotherapy: A Critical Review , Caister Academic Press , Norwich , 2005

5. Twenty years of therapy for HIV-1 infection

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