Imines with rare α-heteroatom substituted amine components generated in situ via the Staudinger/aza-Wittig tandem reaction and their application in multicomponent reactions

Abstract

A series of α-heteroatom substituted methyl azides (XCH2N3, where X = N-HetAr, Sar, OR) have been evaluated for the in situ generation of imines via the Staudinger/aza-Wittig tandem reaction and subsequently coupled with four types of multicomponent reactions.