Design, synthesis, and cell-based <i>in vitro</i> assay of deoxyinosine-mixed SATE-dCDN prodrugs that activate all common STING variants-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

Design, synthesis, and cell-based in vitro assay of deoxyinosine-mixed SATE-dCDN prodrugs that activate all common STING variants

Published:2024 Issue:3 Volume:22 Page:606-620
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Xie Zhiqiang¹,Yang Yuchen¹,Ma Dejun¹,Xi Zhen¹²³⁴^ORCID

Affiliation:

1. State Key Laboratory of Elemento-organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China

2. National Pesticide Engineering Research Centre, Tianjin 300071, China

3. Haihe Laboratory of Sustainable Chemical Transformations, Tianjin 300192, China

4. Collaborative Innovation Centre of Chemical Science and Engineering (Tianjin), Tianjin 300071, China

Abstract

Prodrug 14a exhibited the highest activity and could activate all five most common STING variants.

Funder

Nankai University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D3OB01838E

Reference42 articles.

1. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

2. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

3. Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

4. STING-dependent cytosolic DNA sensing pathways

5. Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Design, synthesis and bioactivity of cyclic dinucleotides against Lepidoptera insects;Advanced Agrochem;2024-09

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号京ICP备18003416号-3