Lanosterol reduces the aggregation propensity of ultraviolet-damaged human γD-crystallins: a molecular dynamics study-Reference-Cited by-同舟云学术

Lanosterol reduces the aggregation propensity of ultraviolet-damaged human γD-crystallins: a molecular dynamics study

Published:2021 Issue:24 Volume:23 Page:13696-13704
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Zhou Hong¹²³⁴⁵,Li Youyun¹²³⁴⁵,Yang Ying¹²³⁴⁵,Liu Shengtang¹²³⁴⁵,Yang Zaixing¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Radiation Medicine and Protection

2. School for Radiological and Interdisciplinary Sciences (RAD-X)

3. Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions

4. Soochow University

5. Suzhou 215123

Abstract

Lanosterol can stabilize the structure of ultraviolet-damaged human γD-crystallins (e.g., tryptophans were photo-oxidized to kynurenines), particularly its N-td, thus reducing its aggregation propensity.

Funder

National Natural Science Foundation of China

Natural Science Research of Jiangsu Higher Education Institutions of China

Priority Academic Program Development of Jiangsu Higher Education Institutions

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CP/D1CP00132A

Reference65 articles.

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