Monitoring amyloid aggregation via a twisted intramolecular charge transfer (TICT)-based fluorescent sensor array

Author:

Wang Chao12,Jiang Wenchao13,Tan Davin2,Huang Lu24,Li Jin13,Qiao Qinglong1,Yadav Priya2,Liu Xiaogang2ORCID,Xu Zhaochao13ORCID

Affiliation:

1. CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China

2. Fluorescence Research Group, Singapore University of Technology and Design, 8 Somapah Road, Singapore 487372, Singapore

3. University of Chinese Academy of Sciences, Beijing 100049, China

4. Ocean College, Minjiang University, Fuzhou 350108, China

Abstract

This work presents an integrative framework for optimizing organic fluorophores' TICT tendency and environmental sensitivities towards various applications. Two newly developed probes could detect the early phase of Aβ aggregation.

Funder

Singapore Institute of Manufacturing Technology

National Natural Science Foundation of China

Ministry of Education - Singapore

Agency for Science, Technology and Research

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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