Defining the conditions for the development of the emerging class of FeIII-based MRI contrast agents

Author:

Baranyai Zsolt1ORCID,Carniato Fabio2ORCID,Nucera Alessandro2,Horváth Dávid13ORCID,Tei Lorenzo2ORCID,Platas-Iglesias Carlos4ORCID,Botta Mauro2ORCID

Affiliation:

1. Bracco Research Centre, Bracco Imaging S.p.A., Via Ribes 5, 10010, Colleretto Giacosa, Italy

2. Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale “A. Avogadro”, Viale T. Michel 11, 15121 Alessandria, Italy

3. Department of Physical Chemistry, University of Debrecen, Egyetem tér 1., H-4010, Debrecen, Hungary

4. Centro de Investigacións Científicas Avanzadas (CICA), Departamento de Química, Facultade de Ciencias, Universidade da Coruña, 15071 A Coruña, Galicia, Spain

Abstract

An integrated 1H and 17O NMR relaxometric study on model systems allowed to highlight that the Fe(III) complexes might represent the best alternative to Gd-based MRI contrast agents at the magnetic fields of current and future clinical scanners.

Funder

Università degli Studi del Piemonte Orientale

Ministerio de Economía y Competitividad

Xunta de Galicia

Debreceni Egyetem

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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