Synthesis and biological evaluation of novel all-hydrocarbon cross-linked aza-stapled peptides-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of novel all-hydrocarbon cross-linked aza-stapled peptides

Published:2022 Issue:40 Volume:20 Page:7963-7971
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Luo Zhihong¹,Xu Lei¹,Tang Xiaomin¹,Zhao Xuejun¹,He Tong¹,Lubell William D.²^ORCID,Zhang Jinqiang¹³^ORCID

Affiliation:

1. Innovative Drug Research Centre (IDRC), Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, P. R. China

2. Département de Chimie, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montréal, Québec H3C 3J7, Canada

3. Chongqing University Industrial Technology Research Institute, Chongqing 401329, People's Republic of China

Abstract

Novel aza-stapled peptides featuring combined structural characteristics of azapeptides and all-hydrocarbon stapled peptides were designed and synthesized for the first time.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01496C

Reference58 articles.

1. Stabilization of protein-protein interactions in drug discovery

2. Fragment‐Based Stabilizers of Protein–Protein Interactions through Imine‐Based Tethering

3. Structure-Based Stabilization of Non-native Protein–Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design

4. Targeting of extracellular protein–protein interactions with macrocyclic peptides

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